The USS Carney, a U.S. Navy destroyer, intercepted multiple projectiles near Yemen on Thursday, the Pentagon said.
The projectiles, which included drones, were brought down near the destroyer without causing any injuries or damage, according to a statement from the Pentagon.
The Pentagon said it was not immediately clear who fired the projectiles, but that they did not appear to be targeting the USS Carney.
The incident comes amid heightened tensions in the region following a series of attacks on U.S. and allied forces in the Middle East.
In July, a U.S. Navy warship was attacked by a drone in the Gulf of Oman. The attack was blamed on Iran, which denied responsibility.
In June, a U.S. base in Syria was attacked by rockets, killing one American service member and injuring several others. The attack was blamed on Iran-backed militias.
The U.S. has accused Iran of using proxies to carry out attacks on its forces in the region. Iran has denied the accusations.
The Pentagon said it is investigating the incident near Yemen and will take all necessary measures to protect U.S. forces.